Cancer cells do not always stay the same throughout the duration of an individual's disease. A recent blog post on Discover Magazine's web site describes how the cancers can change through mutation and selection over time. The post describes changes in acute myeloid leukemia, a disease similar to Jana's chronic myeloid leukemia, but the process can occur in any cancer. The changes parallel the way in which new species arise through natural selection.
http://blogs.discovermagazine.com/loom/2012/01/12/inside-darwins-tumor/
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